Minimal genome-wide human CRISPR-Cas9 library

CRISPR guide RNA libraries have been iteratively improved to provide increasingly efficient reagents, although their large size is a barrier for many applications. We design an optimised minimal genome-wide human CRISPR-Cas9 library (MinLibCas9) by mining existing large-scale gene loss-of-function d...

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Publicat a:Genome Biol
Autors principals: Gonçalves, Emanuel, Thomas, Mark, Behan, Fiona M., Picco, Gabriele, Pacini, Clare, Allen, Felicity, Vinceti, Alessandro, Sharma, Mamta, Jackson, David A., Price, Stacey, Beaver, Charlotte M., Dovey, Oliver, Parry-Smith, David, Iorio, Francesco, Parts, Leopold, Yusa, Kosuke, Garnett, Mathew J.
Format: Artigo
Idioma:Inglês
Publicat: BioMed Central 2021
Matèries:
Short Report
Accés en línia:https://ncbi.nlm.nih.gov/pmc/articles/PMC7818936/
https://ncbi.nlm.nih.gov/pubmed/33478580
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1186/s13059-021-02268-4
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