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Metastasis-associated macrophages constrain antitumor capability of natural killer cells in the metastatic site at least partially by membrane bound transforming growth factor β

BACKGROUND: Metastatic breast cancer is a leading cause of cancer-related death in women worldwide. Infusion of natural killer (NK) cells is an emerging immunotherapy for such malignant tumors, although elimination of the immunosuppressive tumor environment is required to improve its efficacy. The e...

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Detalhes bibliográficos
Publicado no:J Immunother Cancer
Main Authors: Brownlie, Demi, Doughty-Shenton, Dahlia, YH Soong, Daniel, Nixon, Colin, O Carragher, Neil, M Carlin, Leo, Kitamura, Takanori
Formato: Artigo
Idioma:Inglês
Publicado em: BMJ Publishing Group 2021
Assuntos:
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC7818844/
https://ncbi.nlm.nih.gov/pubmed/33472858
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1136/jitc-2020-001740
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