Autosomal dominant VCP hypomorph mutation impairs disaggregation of PHF-tau

Neurodegeneration in Alzheimer’s disease (AD) is closely associated with accumulation of pathologic tau aggregates in the form of neurofibrillary tangles. We found that a p.Asp395Gly mutation in VCP was associated with dementia characterized neuropathologically by neuronal vacuoles and neurofibrilla...

ver descrição completa

Na minha lista:
Detalhes bibliográficos
Publicado no:Science
Main Authors: Darwich, Nabil F., Phan, Jessica M., Kim, Boram, Suh, EunRan, Papatriantafyllou, John D., Changolkar, Lakshmi, Nguyen, Aivi T., O’Rourke, Caroline M., He, Zhuohao, Porta, Sílvia, Gibbons, Garrett S., Luk, Kelvin C., Papageorgiou, Sokratis G., Grossman, Murray, Massimo, Lauren, Irwin, David J., McMillan, Corey T., Nasrallah, Ilya M., Toro, Camilo, Aguirre, Geoffrey K., Van Deerlin, Vivianna M., Lee, Edward B.
Formato: Artigo
Idioma:Inglês
Publicado em: 2020
Assuntos:
Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC7818661/
https://ncbi.nlm.nih.gov/pubmed/33004675
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1126/science.aay8826
Tags: Adicionar Tag
Sem tags, seja o primeiro a adicionar uma tag!

Registos relacionados