APOE and TREM2 regulate amyloid responsive microglia in Alzheimer’s disease

Beta-amyloid deposition is a defining feature of Alzheimer’s disease (AD). How genetic risk factors, like APOE and TREM2, intersect with cellular responses to beta-amyloid in human tissues is not fully understood. Using single-nucleus RNA sequencing of postmortem human brain with varied APOE and TRE...

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Detalhes bibliográficos
Publicado no:Acta Neuropathol
Main Authors: Nguyen, Aivi T., Wang, Kui, Hu, Gang, Wang, Xuran, Miao, Zhen, Azevedo, Joshua A., Suh, EunRan, Van Deerlin, Vivianna M., Choi, David, Roeder, Kathryn, Li, Mingyao, Lee, Edward B.
Formato: Artigo
Idioma:Inglês
Publicado em: 2020
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Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC7520051/
https://ncbi.nlm.nih.gov/pubmed/32840654
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1007/s00401-020-02200-3
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