Quantitative Differentiation of Protein Aggregates From Other Subvisible Particles in Viscous Mixtures Through Holographic Characterization

We demonstrate the use of holographic video microscopy to detect individual subvisible particles dispersed in biopharmaceutical formulations and to differentiate them based on material characteristics measured from their holograms. The result of holographic analysis is a precise and accurate measure...

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Vydáno v:J Pharm Sci
Hlavní autoři: Winters, Annemarie, Cheong, Fook Chiong, Odete, Mary Ann, Lumer, Juliana, Ruffner, David B., Mishra, Kimberly I., Grier, David G., Philips, Laura A.
Médium: Artigo
Jazyk:Inglês
Vydáno: 2020
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Article
On-line přístup:https://ncbi.nlm.nih.gov/pmc/articles/PMC7818018/
https://ncbi.nlm.nih.gov/pubmed/32439328
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.xphs.2020.05.002
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