Quantitative Differentiation of Protein Aggregates From Other Subvisible Particles in Viscous Mixtures Through Holographic Characterization

We demonstrate the use of holographic video microscopy to detect individual subvisible particles dispersed in biopharmaceutical formulations and to differentiate them based on material characteristics measured from their holograms. The result of holographic analysis is a precise and accurate measure...

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Detalhes bibliográficos
Publicado no:J Pharm Sci
Main Authors: Winters, Annemarie, Cheong, Fook Chiong, Odete, Mary Ann, Lumer, Juliana, Ruffner, David B., Mishra, Kimberly I., Grier, David G., Philips, Laura A.
Formato: Artigo
Idioma:Inglês
Publicado em: 2020
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Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC7818018/
https://ncbi.nlm.nih.gov/pubmed/32439328
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.xphs.2020.05.002
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