Mebendazole and temozolomide in patients with newly diagnosed high-grade gliomas: results of a phase 1 clinical trial

BACKGROUND: Mebendazole is an anthelmintic drug introduced for human use in 1971 that extends survival in preclinical models of glioblastoma and other brain cancers. METHODS: A single-center dose-escalation and safety study of mebendazole in 24 patients with newly diagnosed high-grade gliomas in com...

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Vydáno v:Neurooncol Adv
Hlavní autoři: Gallia, Gary L, Holdhoff, Matthias, Brem, Henry, Joshi, Avadhut D, Hann, Christine L, Bai, Ren-Yuan, Staedtke, Verena, Blakeley, Jaishri O, Sengupta, Soma, Jarrell, T Che, Wollett, Jessica, Szajna, Kelly, Helie, Nicole, Mattox, Austin K, Ye, Xiaobu, Rudek, Michelle A, Riggins, Gregory J
Médium: Artigo
Jazyk:Inglês
Vydáno: Oxford University Press 2020
Témata:
Clinical Investigations
On-line přístup:https://ncbi.nlm.nih.gov/pmc/articles/PMC7817892/
https://ncbi.nlm.nih.gov/pubmed/33506200
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1093/noajnl/vdaa154
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