Stronger induction of trained immunity by mucosal BCG or MTBVAC vaccination compared to standard intradermal vaccination

BCG vaccination can strengthen protection against pathogens through the induction of epigenetic and metabolic reprogramming of innate immune cells, a process called trained immunity. We and others recently demonstrated that mucosal or intravenous BCG better protects rhesus macaques from Mycobacteriu...

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Publicat a:Cell Rep Med
Autors principals: Vierboom, Michel P.M., Dijkman, Karin, Sombroek, Claudia C., Hofman, Sam O., Boot, Charelle, Vervenne, Richard A.W., Haanstra, Krista G., van der Sande, Maarten, van Emst, Liesbeth, Domínguez-Andrés, Jorge, Moorlag, Simone J.C.F.M., Kocken, Clemens H.M., Thole, Jelle, Rodríguez, Esteban, Puentes, Eugenia, Martens, Joost H.A., van Crevel, Reinout, Netea, Mihai G., Aguilo, Nacho, Martin, Carlos, Verreck, Frank A.W.
Format: Artigo
Idioma:Inglês
Publicat: Elsevier 2021
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Article
Accés en línia:https://ncbi.nlm.nih.gov/pmc/articles/PMC7817864/
https://ncbi.nlm.nih.gov/pubmed/33521699
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.xcrm.2020.100185
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