Stronger induction of trained immunity by mucosal BCG or MTBVAC vaccination compared to standard intradermal vaccination

BCG vaccination can strengthen protection against pathogens through the induction of epigenetic and metabolic reprogramming of innate immune cells, a process called trained immunity. We and others recently demonstrated that mucosal or intravenous BCG better protects rhesus macaques from Mycobacteriu...

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書誌詳細
出版年:Cell Rep Med
主要な著者: Vierboom, Michel P.M., Dijkman, Karin, Sombroek, Claudia C., Hofman, Sam O., Boot, Charelle, Vervenne, Richard A.W., Haanstra, Krista G., van der Sande, Maarten, van Emst, Liesbeth, Domínguez-Andrés, Jorge, Moorlag, Simone J.C.F.M., Kocken, Clemens H.M., Thole, Jelle, Rodríguez, Esteban, Puentes, Eugenia, Martens, Joost H.A., van Crevel, Reinout, Netea, Mihai G., Aguilo, Nacho, Martin, Carlos, Verreck, Frank A.W.
フォーマット: Artigo
言語:Inglês
出版事項: Elsevier 2021
主題:
Article
オンライン･アクセス:https://ncbi.nlm.nih.gov/pmc/articles/PMC7817864/
https://ncbi.nlm.nih.gov/pubmed/33521699
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.xcrm.2020.100185
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