SOX-5 activates a novel RORγt enhancer to facilitate experimental autoimmune encephalomyelitis by promoting Th17 cell differentiation

T helper type 17 (Th17) cells have important functions in the pathogenesis of inflammatory and autoimmune diseases. Retinoid-related orphan receptor-γt (RORγt) is necessary for Th17 cell differentiation and functions. However, the transcriptional regulation of RORγt expression, especially at the enh...

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Udgivet i:Nat Commun
Main Authors: Tian, Yi, Han, Chao, Wei, Zhiyuan, Dong, Hui, Shen, Xiaohe, Cui, Yiqiang, Fu, Xiaolan, Tian, Zhiqiang, Wang, Shufeng, Zhou, Jian, Yang, Di, Sun, Yi, Yuan, Jizhao, Ni, Bing, Wu, Yuzhang
Format: Artigo
Sprog:Inglês
Udgivet: Nature Publishing Group UK 2021
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Article
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC7817841/
https://ncbi.nlm.nih.gov/pubmed/33473108
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/s41467-020-20786-w
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