RORγt-specific transcriptional interactomic inhibition suppresses autoimmunity associated with T(H)17 cells

The nuclear hormone receptor retinoic acid-related orphan receptor gamma t (RORγt) is a transcription factor (TF) specific to T(H)17 cells that produce interleukin (IL)-17 and have been implicated in a wide range of autoimmunity. Here, we developed a novel therapeutic strategy to modulate the functi...

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Detalhes bibliográficos
Publicado no:Proc Natl Acad Sci U S A
Main Authors: Park, Tae-Yoon, Park, Sung-Dong, Cho, Jen-Young, Moon, Jae-Seung, Kim, Na-Yeon, Park, Kyungsoo, Seong, Rho Hyun, Lee, Sang-Won, Morio, Tomohiro, Bothwell, Alfred L. M., Lee, Sang-Kyou
Formato: Artigo
Idioma:Inglês
Publicado em: National Academy of Sciences 2014
Assuntos:
Biological Sciences
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC4284575/
https://ncbi.nlm.nih.gov/pubmed/25527718
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1073/pnas.1413687112
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