Adaptive responses to mTOR gene targeting in hematopoietic stem cells reveal a proliferative mechanism evasive to mTOR inhibition

The mechanistic target of rapamycin (mTOR) is a central regulator of cell growth and an attractive anticancer target that integrates diverse signals to control cell proliferation. Previous studies using mTOR inhibitors have shown that mTOR targeting suppresses gene expression and cell proliferation....

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Enregistré dans:
Détails bibliographiques
Publié dans:Proc Natl Acad Sci U S A
Auteurs principaux: Fan, Cuiqing, Zhao, Chuntao, Zhang, Feng, Kesarwani, Meenu, Tu, Zhaowei, Cai, Xiongwei, Davis, Ashley Kuenzi, Xu, Lingli, Hochstetler, Cindy L., Chen, Xiaoyi, Guo, Fukun, Huang, Gang, Azam, Mohammad, Tian, Weidong, Lu, Q. Richard, Zheng, Yi
Format: Artigo
Langue:Inglês
Publié: National Academy of Sciences 2021
Sujets:
Biological Sciences
Accès en ligne:https://ncbi.nlm.nih.gov/pmc/articles/PMC7817152/
https://ncbi.nlm.nih.gov/pubmed/33443202
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1073/pnas.2020102118
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