Adaptive responses to mTOR gene targeting in hematopoietic stem cells reveal a proliferative mechanism evasive to mTOR inhibition

The mechanistic target of rapamycin (mTOR) is a central regulator of cell growth and an attractive anticancer target that integrates diverse signals to control cell proliferation. Previous studies using mTOR inhibitors have shown that mTOR targeting suppresses gene expression and cell proliferation....

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Detalhes bibliográficos
Publicado no:Proc Natl Acad Sci U S A
Main Authors: Fan, Cuiqing, Zhao, Chuntao, Zhang, Feng, Kesarwani, Meenu, Tu, Zhaowei, Cai, Xiongwei, Davis, Ashley Kuenzi, Xu, Lingli, Hochstetler, Cindy L., Chen, Xiaoyi, Guo, Fukun, Huang, Gang, Azam, Mohammad, Tian, Weidong, Lu, Q. Richard, Zheng, Yi
Formato: Artigo
Idioma:Inglês
Publicado em: National Academy of Sciences 2021
Assuntos:
Biological Sciences
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC7817152/
https://ncbi.nlm.nih.gov/pubmed/33443202
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1073/pnas.2020102118
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