Adaptive responses to mTOR gene targeting in hematopoietic stem cells reveal a proliferative mechanism evasive to mTOR inhibition

The mechanistic target of rapamycin (mTOR) is a central regulator of cell growth and an attractive anticancer target that integrates diverse signals to control cell proliferation. Previous studies using mTOR inhibitors have shown that mTOR targeting suppresses gene expression and cell proliferation....

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Detaylı Bibliyografya
Yayımlandı:Proc Natl Acad Sci U S A
Asıl Yazarlar: Fan, Cuiqing, Zhao, Chuntao, Zhang, Feng, Kesarwani, Meenu, Tu, Zhaowei, Cai, Xiongwei, Davis, Ashley Kuenzi, Xu, Lingli, Hochstetler, Cindy L., Chen, Xiaoyi, Guo, Fukun, Huang, Gang, Azam, Mohammad, Tian, Weidong, Lu, Q. Richard, Zheng, Yi
Materyal Türü: Artigo
Dil:Inglês
Baskı/Yayın Bilgisi: National Academy of Sciences 2021
Konular:
Biological Sciences
Online Erişim:https://ncbi.nlm.nih.gov/pmc/articles/PMC7817152/
https://ncbi.nlm.nih.gov/pubmed/33443202
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1073/pnas.2020102118
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