Targeting transcriptional regulation of SARS-CoV-2 entry factors ACE2 and TMPRSS2

Severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2), the virus responsible for COVID-19, employs two key host proteins to gain entry and replicate within cells, angiotensin-converting enzyme 2 (ACE2) and the cell surface transmembrane protease serine 2 (TMPRSS2). TMPRSS2 was first character...

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Detalhes bibliográficos
Publicado no:Proc Natl Acad Sci U S A
Main Authors: Qiao, Yuanyuan, Wang, Xiao-Ming, Mannan, Rahul, Pitchiaya, Sethuramasundaram, Zhang, Yuping, Wotring, Jesse W., Xiao, Lanbo, Robinson, Dan R., Wu, Yi-Mi, Tien, Jean Ching-Yi, Cao, Xuhong, Simko, Stephanie A., Apel, Ingrid J., Bawa, Pushpinder, Kregel, Steven, Narayanan, Sathiya P., Raskind, Gregory, Ellison, Stephanie J., Parolia, Abhijit, Zelenka-Wang, Sylvia, McMurry, Lisa, Su, Fengyun, Wang, Rui, Cheng, Yunhui, Delekta, Andrew D., Mei, Zejie, Pretto, Carla D., Wang, Shaomeng, Mehra, Rohit, Sexton, Jonathan Z., Chinnaiyan, Arul M.
Formato: Artigo
Idioma:Inglês
Publicado em: National Academy of Sciences 2021
Assuntos:
Biological Sciences
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC7817128/
https://ncbi.nlm.nih.gov/pubmed/33310900
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1073/pnas.2021450118
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