Multivalent proteins rapidly and reversibly phase-separate upon osmotic cell volume change

Processing bodies (PB) and stress granules (SG) are prominent examples of sub-cellular, membrane-less compartments that are observed under physiological and stress conditions, respectively. We observe that the trimeric PB protein DCP1A rapidly (within ~10 s) phase-separates in mammalian cells during...

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Foilsithe in:Mol Cell
Main Authors: Jalihal, Ameya P., Pitchiaya, Sethuramasundaram, Xiao, Lanbo, Bawa, Pushpinder, Jiang, Xia, Bedi, Karan, Parolia, Abhijit, Cieslik, Marcin, Ljungman, Mats, Chinnaiyan, Arul M., Walter, Nils G.
Formáid: Artigo
Teanga:Inglês
Foilsithe: 2020
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Article
Rochtain Ar Líne:https://ncbi.nlm.nih.gov/pmc/articles/PMC7502480/
https://ncbi.nlm.nih.gov/pubmed/32857953
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.molcel.2020.08.004
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