Mechanistic insights into the synergistic activation of the RXR–PXR heterodimer by endocrine disruptor mixtures

Humans are chronically exposed to mixtures of xenobiotics referred to as endocrine-disrupting chemicals (EDCs). A vast body of literature links exposure to these chemicals with increased incidences of reproductive, metabolic, or neurological disorders. Moreover, recent data demonstrate that, when us...

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Detalhes bibliográficos
Publicado no:Proc Natl Acad Sci U S A
Main Authors: Delfosse, Vanessa, Huet, Tiphaine, Harrus, Deborah, Granell, Meritxell, Bourguet, Maxime, Gardia-Parège, Caroline, Chiavarina, Barbara, Grimaldi, Marina, Le Mével, Sébastien, Blanc, Pauline, Huang, David, Gruszczyk, Jakub, Demeneix, Barbara, Cianférani, Sarah, Fini, Jean-Baptiste, Balaguer, Patrick, Bourguet, William
Formato: Artigo
Idioma:Inglês
Publicado em: National Academy of Sciences 2021
Assuntos:
Biological Sciences
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC7817120/
https://ncbi.nlm.nih.gov/pubmed/33361153
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1073/pnas.2020551118
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