IL-10 and class 1 histone deacetylases act synergistically and independently on the secretion of proinflammatory mediators in alveolar macrophages

INTRODUCTION: Anti-inflammatory cytokine IL-10 suppresses pro-inflammatory IL-12b expression after Lipopolysaccharide (LPS) stimulation in colonic macrophages, as part of the innate immunity Toll-Like Receptor (TLR)-NF-κB activation system. This homeostatic mechanism limits excess inflammation in th...

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Detalhes bibliográficos
Publicado no:PLoS One
Main Authors: Stanfield, Brent A., Purves, Todd, Palmer, Scott, Sullenger, Bruce, Welty-Wolf, Karen, Haines, Krista, Agarwal, Suresh, Kasotakis, George
Formato: Artigo
Idioma:Inglês
Publicado em: Public Library of Science 2021
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Research Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC7816993/
https://ncbi.nlm.nih.gov/pubmed/33471802
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1371/journal.pone.0245169
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