Elevated inflammatory gene expression in intervertebral disc tissues in mice with ADAM8 inactivated

We found ADAM8 enzymatic activity elevated in degenerative human intervertebral disc (IVD). Here, we examined the discs in ADAM8-inactivation mice that carry a mutation preventing self-activation of the enzyme. Surprisingly, elevated gene expression for inflammatory markers (Cxcl1, IL6) was observed...

ver descrição completa

Na minha lista:
Detalhes bibliográficos
Publicado no:Sci Rep
Main Authors: Zhang, Yejia, Tian, Zuozhen, Gerard, David, Yao, Lutian, Shofer, Frances S., Cs-Szabo, Gabriella, Qin, Ling, Pacifici, Maurizio, Enomoto-Iwamoto, Motomi
Formato: Artigo
Idioma:Inglês
Publicado em: Nature Publishing Group UK 2021
Assuntos:
Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC7815795/
https://ncbi.nlm.nih.gov/pubmed/33469101
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/s41598-021-81495-y
Tags: Adicionar Tag
Sem tags, seja o primeiro a adicionar uma tag!

Registos relacionados