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Elevated inflammatory gene expression in intervertebral disc tissues in mice with ADAM8 inactivated
We found ADAM8 enzymatic activity elevated in degenerative human intervertebral disc (IVD). Here, we examined the discs in ADAM8-inactivation mice that carry a mutation preventing self-activation of the enzyme. Surprisingly, elevated gene expression for inflammatory markers (Cxcl1, IL6) was observed...
Tallennettuna:
| Julkaisussa: | Sci Rep |
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| Päätekijät: | , , , , , , , , |
| Aineistotyyppi: | Artigo |
| Kieli: | Inglês |
| Julkaistu: |
Nature Publishing Group UK
2021
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| Aiheet: | |
| Linkit: | https://ncbi.nlm.nih.gov/pmc/articles/PMC7815795/ https://ncbi.nlm.nih.gov/pubmed/33469101 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/s41598-021-81495-y |
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