Elevated inflammatory gene expression in intervertebral disc tissues in mice with ADAM8 inactivated

We found ADAM8 enzymatic activity elevated in degenerative human intervertebral disc (IVD). Here, we examined the discs in ADAM8-inactivation mice that carry a mutation preventing self-activation of the enzyme. Surprisingly, elevated gene expression for inflammatory markers (Cxcl1, IL6) was observed...

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Publicat a:Sci Rep
Autors principals: Zhang, Yejia, Tian, Zuozhen, Gerard, David, Yao, Lutian, Shofer, Frances S., Cs-Szabo, Gabriella, Qin, Ling, Pacifici, Maurizio, Enomoto-Iwamoto, Motomi
Format: Artigo
Idioma:Inglês
Publicat: Nature Publishing Group UK 2021
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Article
Accés en línia:https://ncbi.nlm.nih.gov/pmc/articles/PMC7815795/
https://ncbi.nlm.nih.gov/pubmed/33469101
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/s41598-021-81495-y
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