Effect of Formulation Variables on the Stability of a Live, Rotavirus (RV3-BB) Vaccine Candidate using in vitro Gastric Digestion Models to Mimic Oral Delivery

In this work, two different in vitro gastric digestion models were used to evaluate the stability of a live attenuated rotavirus vaccine candidate (RV3-BB) under conditions designed to mimic oral delivery in infants. First, a forced-degradation model was established at low pH to assess the buffering...

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Bibliografski detalji
Izdano u:J Pharm Sci
Glavni autori: Kumar, Prashant, Pullagurla, Swathi R., Patel, Ashaben, Shukla, Ravi S., Bird, Christopher, Kumru, Ozan S., Hamidi, Ahd, Hoeksema, Femke, Yallop, Christopher, Bines, Julie E., Joshi, Sangeeta B., Volkin, David B.
Format: Artigo
Jezik:Inglês
Izdano: Elsevier 2021
Teme:
Research Article
Online pristup:https://ncbi.nlm.nih.gov/pmc/articles/PMC7815322/
https://ncbi.nlm.nih.gov/pubmed/33035539
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.xphs.2020.09.047
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