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Identification of Adenosine Deaminase Inhibitors by Metal-binding Pharmacophore Screening

Adenosine deaminase (ADA) is a human mononuclear Zn(2+) metalloenzyme that converts adenosine to inosine. ADA is a validated drug target for cancer, but there has been little recent work on the development of new therapeutics against this enzyme. The lack of new advancements can be partially attribu...

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Publicado en:ChemMedChem
Autores principales: Adamek, Rebecca N., Ludford, Paul, Duggan, Stephanie M., Tor, Yitzhak, Cohen, Seth M.
Formato: Artigo
Lenguaje:Inglês
Publicado: 2020
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Acceso en línea:https://ncbi.nlm.nih.gov/pmc/articles/PMC7815202/
https://ncbi.nlm.nih.gov/pubmed/32729197
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1002/cmdc.202000271
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