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Structures of human Pannexin 1 reveal ion pathways and mechanism of gating
Pannexin 1 (PANX1) is an ATP-permeable channel crucially involved in a variety of physiological functions such as blood pressure regulation(1), apoptotic cell clearance(2), and human oocyte development(3). We present several human PANX1 structures in a heptameric assembly at resolutions up to 2.8 Å,...
Salvato in:
| Pubblicato in: | Nature |
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| Autori principali: | , , , |
| Natura: | Artigo |
| Lingua: | Inglês |
| Pubblicazione: |
2020
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| Soggetti: | |
| Accesso online: | https://ncbi.nlm.nih.gov/pmc/articles/PMC7814660/ https://ncbi.nlm.nih.gov/pubmed/32494015 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/s41586-020-2357-y |
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