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The Cryo-EM structure of pannexin 1 reveals unique motifs for ion selection and inhibition

Pannexins are large-pore forming channels responsible for ATP release under a variety of physiological and pathological conditions. Although predicted to share similar membrane topology with other large-pore forming proteins such as connexins, innexins, and LRRC8, pannexins have minimal sequence sim...

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Detalhes bibliográficos
Publicado no:eLife
Main Authors: Michalski, Kevin, Syrjanen, Johanna L, Henze, Erik, Kumpf, Julia, Furukawa, Hiro, Kawate, Toshimitsu
Formato: Artigo
Idioma:Inglês
Publicado em: eLife Sciences Publications, Ltd 2020
Assuntos:
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC7108861/
https://ncbi.nlm.nih.gov/pubmed/32048993
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.7554/eLife.54670
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