Spreading of TDP-43 pathology via pyramidal tract induces ALS-like phenotypes in TDP-43 transgenic mice

Transactive response DNA-binding protein 43 kDa (TDP-43) has been identified as the major component of ubiquitinated inclusions found in patients with sporadic amyotrophic lateral sclerosis (ALS). Increasing evidence suggests prion-like transmission of TDP-43 aggregates via neuroanatomic connection...

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Enregistré dans:
Détails bibliographiques
Publié dans:Acta Neuropathol Commun
Auteurs principaux: Ding, Xuebing, Xiang, Zhi, Qin, Chi, Chen, Yongkang, Tian, Haiyan, Meng, Lin, Xia, Danhao, Liu, Han, Song, Jia, Fu, Jun, Ma, Mingming, Wang, Xuejing
Format: Artigo
Langue:Inglês
Publié: BioMed Central 2021
Sujets:
Research
Accès en ligne:https://ncbi.nlm.nih.gov/pmc/articles/PMC7814549/
https://ncbi.nlm.nih.gov/pubmed/33461623
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1186/s40478-020-01112-3
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