Spreading of pathological TDP-43 along corticospinal tract axons induces ALS-like phenotypes in Atg5(+/-) mice

Amyotrophic lateral sclerosis (ALS) is a progressive neurodegenerative disease, characterized by phosphorylated TDP-43 (pTDP-43)-positive inclusions in neurons and glial cells. However, the pathogenic mechanism that underlies ALS remains largely unknown. To investigate the effects of autophagy defic...

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Enregistré dans:
Détails bibliographiques
Publié dans:Int J Biol Sci
Auteurs principaux: Zhang, Rui, Chen, Yongkang, Wang, Xinxin, Tian, Haiyan, Liu, Han, Xiang, Zhi, Qi, Dan, Huang, Jason H., Wu, Erxi, Ding, Xuebing, Wang, Xuejing
Format: Artigo
Langue:Inglês
Publié: Ivyspring International Publisher 2021
Sujets:
Research Paper
Accès en ligne:https://ncbi.nlm.nih.gov/pmc/articles/PMC7893595/
https://ncbi.nlm.nih.gov/pubmed/33613100
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.7150/ijbs.53872
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