Re-expression of SMARCA4/BRG1 in small cell carcinoma of ovary, hypercalcemic type (SCCOHT) promotes an epithelial-like gene signature through an AP-1-dependent mechanism

Small cell carcinoma of the ovary, hypercalcemic type (SCCOHT) is a rare and aggressive form of ovarian cancer. SCCOHT tumors have inactivating mutations in SMARCA4 (BRG1), one of the two mutually exclusive ATPases of the SWI/SNF chromatin remodeling complex. To address the role that BRG1 loss plays...

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Detalhes bibliográficos
Publicado no:eLife
Main Authors: Orlando, Krystal Ann, Douglas, Amber K, Abudu, Aierken, Wang, Yemin, Tessier-Cloutier, Basile, Su, Weiping, Peters, Alec, Sherman, Larry S, Moore, Rayvon, Nguyen, Vinh, Negri, Gian Luca, Colborne, Shane, Morin, Gregg B, Kommoss, Friedrich, Lang, Jessica D, Hendricks, William PD, Raupach, Elizabeth A, Pirrotte, Patrick, Huntsman, David G, Trent, Jeffrey M, Parker, Joel S, Raab, Jesse R, Weissman, Bernard E
Formato: Artigo
Idioma:Inglês
Publicado em: eLife Sciences Publications, Ltd 2020
Assuntos:
Cancer Biology
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC7813545/
https://ncbi.nlm.nih.gov/pubmed/33355532
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.7554/eLife.59073
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