Dual loss of the SWI/SNF complex ATPases SMARCA4/BRG1 and SMARCA2/BRM is highly sensitive and specific for small cell carcinoma of the ovary, hypercalcaemic type

Small cell carcinoma of the ovary, hypercalcaemic type (SCCOHT) is a lethal and sometimes familial ovarian tumour of young women and children. We and others recently discovered that over 90% of SCCOHTs harbour inactivating mutations in the chromatin remodelling gene SMARCA4 with concomitant loss of...

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Detalhes bibliográficos
Publicado no:J Pathol
Main Authors: Karnezis, Anthony N, Wang, Yemin, Ramos, Pilar, Hendricks, William PD, Oliva, Esther, D'Angelo, Emanuela, Prat, Jaime, Nucci, Marisa R, Nielsen, Torsten O, Chow, Christine, Leung, Samuel, Kommoss, Friedrich, Kommoss, Stefan, Silva, Annacarolina, Ronnett, Brigitte M, Rabban, Joseph T, Bowtell, David D, Weissman, Bernard E, Trent, Jeffrey M, Gilks, C Blake, Huntsman, David G
Formato: Artigo
Idioma:Inglês
Publicado em: John Wiley & Sons, Ltd 2015
Assuntos:
Original Papers
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC4832362/
https://ncbi.nlm.nih.gov/pubmed/26356327
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1002/path.4633
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