Ponatinib shows potent antitumor activity in small cell carcinoma of the ovary hypercalcemic type (SCCOHT) through multi-kinase inhibition

PURPOSE: Small cell carcinoma of the ovary, hypercalcemic type (SCCOHT) is a rare, aggressive ovarian cancer in young women that is universally driven by loss of the SWI/SNF ATPase subunits SMARCA4 and SMARCA2. A great need exists for effective targeted therapies for SCCOHT. EXPERIMENTAL DESIGN: To...

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Publicado en:Clin Cancer Res
Main Authors: Lang, Jessica D., Hendricks, William P. D., Orlando, Krystal A., Yin, Hongwei Holly, Kiefer, Jeffrey, Ramos, Pilar, Sharma, Ritin, Pirrotte, Patrick, Raupach, Elizabeth A, Sereduk, Chris, Tang, Nanyun, Liang, Winnie, Washington, Megan, Facista, Salvatore J., Zismann, Victoria L., Cousins, Emily M., Major, Michael B., Wang, Yemin, Karnezis, Anthony N., Sekulic, Aleksandar, Hass, Ralf, Vanderhyden, Barbara, Praveen, Kesavannair, Weissman, Bernard E., Huntsman, David G., Trent, Jeffrey M.
Formato: Artigo
Idioma:Inglês
Publicado: 2018
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Article
Acceso en liña:https://ncbi.nlm.nih.gov/pmc/articles/PMC6526947/
https://ncbi.nlm.nih.gov/pubmed/29440177
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1158/1078-0432.CCR-17-1928
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