Ponatinib shows potent antitumor activity in small cell carcinoma of the ovary hypercalcemic type (SCCOHT) through multi-kinase inhibition

PURPOSE: Small cell carcinoma of the ovary, hypercalcemic type (SCCOHT) is a rare, aggressive ovarian cancer in young women that is universally driven by loss of the SWI/SNF ATPase subunits SMARCA4 and SMARCA2. A great need exists for effective targeted therapies for SCCOHT. EXPERIMENTAL DESIGN: To...

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Bibliografski detalji
Izdano u:Clin Cancer Res
Glavni autori: Lang, Jessica D., Hendricks, William P. D., Orlando, Krystal A., Yin, Hongwei Holly, Kiefer, Jeffrey, Ramos, Pilar, Sharma, Ritin, Pirrotte, Patrick, Raupach, Elizabeth A, Sereduk, Chris, Tang, Nanyun, Liang, Winnie, Washington, Megan, Facista, Salvatore J., Zismann, Victoria L., Cousins, Emily M., Major, Michael B., Wang, Yemin, Karnezis, Anthony N., Sekulic, Aleksandar, Hass, Ralf, Vanderhyden, Barbara, Praveen, Kesavannair, Weissman, Bernard E., Huntsman, David G., Trent, Jeffrey M.
Format: Artigo
Jezik:Inglês
Izdano: 2018
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Article
Online pristup:https://ncbi.nlm.nih.gov/pmc/articles/PMC6526947/
https://ncbi.nlm.nih.gov/pubmed/29440177
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1158/1078-0432.CCR-17-1928
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