Insertions of codons encoding basic amino acids in H7 hemagglutinins of influenza A viruses occur by recombination with RNA at hotspots near snoRNA binding sites

The presence of multiple basic amino acids in the protease cleavage site of the hemagglutinin (HA) protein is the main molecular determinant of virulence of highly pathogenic avian influenza (HPAI) viruses. Recombination of HA RNA with other RNA molecules of host or virus origin is a dominant mechan...

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Bibliographic Details
Published in:RNA
Main Authors: Gultyaev, Alexander P., Spronken, Monique I., Funk, Mathis, Fouchier, Ron A.M., Richard, Mathilde
Format: Artigo
Language:Inglês
Published: Cold Spring Harbor Laboratory Press 2021
Subjects:
Hypothesis
Online Access:https://ncbi.nlm.nih.gov/pmc/articles/PMC7812872/
https://ncbi.nlm.nih.gov/pubmed/33188057
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1261/rna.077495.120
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