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Analysis of Human Small Nucleolar RNAs (snoRNA) and the Development of snoRNA Modulator of Gene Expression Vectors

Human small nucleolar RNAs (snoRNAs) that copurify with nucleoli isolated from HeLa cells have been characterized. Novel fibrillarin-associated snoRNAs were detected that allowed the creation of a new vector system for the targeted knockdown of one or more genes in mammalian cells. The snoMEN (snoRN...

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Autors principals: Ono, Motoharu, Yamada, Kayo, Avolio, Fabio, Scott, Michelle S., van Koningsbruggen, Silvana, Barton, Geoffrey J., Lamond, Angus I.
Format: Artigo
Idioma:Inglês
Publicat: The American Society for Cell Biology 2010
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Accés en línia:https://ncbi.nlm.nih.gov/pmc/articles/PMC2861615/
https://ncbi.nlm.nih.gov/pubmed/20219969
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1091/mbc.E10-01-0078
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