T(FH) cells depend on Tcf1-intrinsic HDAC activity to suppress CTLA4 and guard B-cell help function

Precise regulation of coinhibitory receptors is essential for maintaining immune tolerance without interfering with protective immunity, yet the mechanism underlying such a balanced act remains poorly understood. In response to protein immunization, T follicular helper (T(FH)) cells lacking Tcf1 and...

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Detalhes bibliográficos
Publicado no:Proc Natl Acad Sci U S A
Main Authors: Li, Fengyin, Zhao, Xin, Zhang, Yali, Shao, Peng, Ma, Xiaoke, Paradee, William J., Liu, Chengyu, Wang, Jianmin, Xue, Hai-Hui
Formato: Artigo
Idioma:Inglês
Publicado em: National Academy of Sciences 2021
Assuntos:
Biological Sciences
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC7812797/
https://ncbi.nlm.nih.gov/pubmed/33372138
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1073/pnas.2014562118
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