ADP-ribose and analogues bound to the deMARylating macrodomain from the bat coronavirus HKU4

Macrodomains are proteins that recognize and hydrolyze ADP ribose (ADPR) modifications of intracellular proteins. Macrodomains are implicated in viral genome replication and interference with host cell immune responses. They are important to the infectious cycle of Coronaviridae and Togaviridae viru...

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Detalhes bibliográficos
Publicado no:Proc Natl Acad Sci U S A
Principais autores: Hammond, Robert G., Schormann, Norbert, McPherson, Robert Lyle, Leung, Anthony K. L., Deivanayagam, Champion C. S., Johnson, Margaret A.
Formato: Artigo
Idioma:Inglês
Publicado em: National Academy of Sciences 2021
Assuntos:
Biological Sciences
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC7812796/
https://ncbi.nlm.nih.gov/pubmed/33397718
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1073/pnas.2004500118
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