Discovery of a Pyrimidothiazolodiazepinone as a Potent and Selective Focal Adhesion Kinase (FAK) Inhibitor

[Image: see text] Focal adhesion kinase (FAK) is a tyrosine kinase with prominent roles in protein scaffolding, migration, angiogenesis, and anchorage-independent cell survival and is an attractive target for the development of cancer therapeutics. However, current FAK inhibitors display dual kinase...

पूर्ण विवरण

में बचाया:
ग्रंथसूची विवरण
में प्रकाशित:ACS Med Chem Lett
मुख्य लेखकों: Groendyke, Brian J., Nabet, Behnam, Mohardt, Mikaela L., Zhang, Haisheng, Peng, Ke, Koide, Eriko, Coffey, Calvin R., Che, Jianwei, Scott, David A., Bass, Adam J., Gray, Nathanael S.
स्वरूप: Artigo
भाषा:Inglês
प्रकाशित: American Chemical Society 2020
ऑनलाइन पहुंच:https://ncbi.nlm.nih.gov/pmc/articles/PMC7812608/
https://ncbi.nlm.nih.gov/pubmed/33488961
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1021/acsmedchemlett.0c00338
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