Targeted Deletion of Interleukin-6 in a Mouse Model of Chronic Inflammation Demonstrates Opposing Roles in Aging: Benefit and Harm

Chronic inflammation (CI) in older adults is associated with reduced health span and life span. Interleukin-6 (IL-6) is one CI marker that is strongly associated with adverse health outcomes and mortality in aging. We have previously characterized a mouse model of frailty and chronic inflammatory pa...

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Vydáno v:J Gerontol A Biol Sci Med Sci
Hlavní autoři: Ma, Lina, Nidadavolu, Lolita S, Yang, Huanle, Langdon, Jackie, Westbrook, Reyhan, Tsui, Benjamin M W, Lee, Taek-Soo, Hinson, Jared, Ling, Shizhang, Marx-Rattner, Ruth, Wu, Yuqiong, Nguyen, Tu, Tan, Jessica, Khadeer, Mohammed, Moaddel, Ruin, Le, Anne, Walston, Jeremy D, Abadir, Peter M
Médium: Artigo
Jazyk:Inglês
Vydáno: Oxford University Press 2020
Témata:
THE JOURNAL OF GERONTOLOGY: Biological Sciences
On-line přístup:https://ncbi.nlm.nih.gov/pmc/articles/PMC7812426/
https://ncbi.nlm.nih.gov/pubmed/32585682
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1093/gerona/glaa156
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