ICOSL(+) plasmacytoid dendritic cells as inducer of graft-versus-host disease, responsive to a dual ICOS/CD28 antagonist

Acute graft-versus-host disease (aGVHD) remains a major complication of allogeneic hematopoietic cell transplantation (HCT). CD146 and CCR5 are proteins that mark activated T helper 17 (Th17) cells. The Th17 cell phenotype is promoted by the interaction of the receptor ICOS on T cells with ICOS liga...

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Publicat a:Sci Transl Med
Autors principals: Adom, Djamilatou, Dillon, Stacey R., Yang, Jinfeng, Liu, Hao, Ramadan, Abdulraouf, Kushekhar, Kushi, Hund, Samantha, Albright, Amanda, Kirksey, Maykala, Adeniyan, Titilayo, Lewis, Katherine E., Evans, Lawrence, Wu, Rebecca, Levin, Steven D., Mudri, Sherri, Yang, Jing, Rickel, Erika, Seaberg, Michelle, Henderson, Katherine, Gudgeon, Chelsea J., Wolfson, Martin F., Swanson, Ryan M., Swiderek, Kristine M., Peng, Stanford L., Hippen, Keli L., Blazar, Bruce R., Paczesny, Sophie
Format: Artigo
Idioma:Inglês
Publicat: 2020
Matèries:
Article
Accés en línia:https://ncbi.nlm.nih.gov/pmc/articles/PMC7811191/
https://ncbi.nlm.nih.gov/pubmed/33028709
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1126/scitranslmed.aay4799
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