ICOSL(+) plasmacytoid dendritic cells as inducer of graft-versus-host disease, responsive to a dual ICOS/CD28 antagonist

Acute graft-versus-host disease (aGVHD) remains a major complication of allogeneic hematopoietic cell transplantation (HCT). CD146 and CCR5 are proteins that mark activated T helper 17 (Th17) cells. The Th17 cell phenotype is promoted by the interaction of the receptor ICOS on T cells with ICOS liga...

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Veröffentlicht in:Sci Transl Med
Hauptverfasser: Adom, Djamilatou, Dillon, Stacey R., Yang, Jinfeng, Liu, Hao, Ramadan, Abdulraouf, Kushekhar, Kushi, Hund, Samantha, Albright, Amanda, Kirksey, Maykala, Adeniyan, Titilayo, Lewis, Katherine E., Evans, Lawrence, Wu, Rebecca, Levin, Steven D., Mudri, Sherri, Yang, Jing, Rickel, Erika, Seaberg, Michelle, Henderson, Katherine, Gudgeon, Chelsea J., Wolfson, Martin F., Swanson, Ryan M., Swiderek, Kristine M., Peng, Stanford L., Hippen, Keli L., Blazar, Bruce R., Paczesny, Sophie
Format: Artigo
Sprache:Inglês
Veröffentlicht: 2020
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Article
Online Zugang:https://ncbi.nlm.nih.gov/pmc/articles/PMC7811191/
https://ncbi.nlm.nih.gov/pubmed/33028709
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1126/scitranslmed.aay4799
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