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A high-throughput cell-based assay pipeline for the preclinical development of bacterial DsbA inhibitors as antivirulence therapeutics

Antibiotics are failing fast, and the development pipeline remains alarmingly dry. New drug research and development is being urged by world health officials, with new antibacterials against multidrug-resistant Gram-negative pathogens as the highest priority. Antivirulence drugs, which inhibit bacte...

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Detalhes bibliográficos
Publicado no:Sci Rep
Main Authors: Verderosa, Anthony D., Dhouib, Rabeb, Hong, Yaoqin, Anderson, Taylah K., Heras, Begoña, Totsika, Makrina
Formato: Artigo
Idioma:Inglês
Publicado em: Nature Publishing Group UK 2021
Assuntos:
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC7810732/
https://ncbi.nlm.nih.gov/pubmed/33452354
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/s41598-021-81007-y
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