Oxidized CaMKII and O-GlcNAcylation cause increased atrial fibrillation in diabetic mice by distinct mechanisms

Diabetes mellitus (DM) and atrial fibrillation (AF) are major unsolved public health problems, and diabetes is an independent risk factor for AF. However, the mechanism(s) underlying this clinical association is unknown. ROS and protein O-GlcNAcylation (OGN) are increased in diabetic hearts, and cal...

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שמור ב:
מידע ביבליוגרפי
הוצא לאור ב:J Clin Invest
Main Authors: Mesubi, Olurotimi O., Rokita, Adam G., Abrol, Neha, Wu, Yuejin, Chen, Biyi, Wang, Qinchuan, Granger, Jonathan M., Tucker-Bartley, Anthony, Luczak, Elizabeth D., Murphy, Kevin R., Umapathi, Priya, Banerjee, Partha S., Boronina, Tatiana N., Cole, Robert N., Maier, Lars S., Wehrens, Xander H., Pomerantz, Joel L., Song, Long-Sheng, Ahima, Rexford S., Hart, Gerald W., Zachara, Natasha E., Anderson, Mark E.
פורמט: Artigo
שפה:Inglês
יצא לאור: American Society for Clinical Investigation 2021
נושאים:
Research Article
גישה מקוונת:https://ncbi.nlm.nih.gov/pmc/articles/PMC7810480/
https://ncbi.nlm.nih.gov/pubmed/33151911
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1172/JCI95747
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