Oxidized CaMKII and O-GlcNAcylation cause increased atrial fibrillation in diabetic mice by distinct mechanisms

Diabetes mellitus (DM) and atrial fibrillation (AF) are major unsolved public health problems, and diabetes is an independent risk factor for AF. However, the mechanism(s) underlying this clinical association is unknown. ROS and protein O-GlcNAcylation (OGN) are increased in diabetic hearts, and cal...

Descripción completa

Guardado en:
Detalles Bibliográficos
Publicado en:J Clin Invest
Autores principales: Mesubi, Olurotimi O., Rokita, Adam G., Abrol, Neha, Wu, Yuejin, Chen, Biyi, Wang, Qinchuan, Granger, Jonathan M., Tucker-Bartley, Anthony, Luczak, Elizabeth D., Murphy, Kevin R., Umapathi, Priya, Banerjee, Partha S., Boronina, Tatiana N., Cole, Robert N., Maier, Lars S., Wehrens, Xander H., Pomerantz, Joel L., Song, Long-Sheng, Ahima, Rexford S., Hart, Gerald W., Zachara, Natasha E., Anderson, Mark E.
Formato: Artigo
Lenguaje:Inglês
Publicado: American Society for Clinical Investigation 2021
Materias:
Research Article
Acceso en línea:https://ncbi.nlm.nih.gov/pmc/articles/PMC7810480/
https://ncbi.nlm.nih.gov/pubmed/33151911
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1172/JCI95747
Etiquetas: Agregar Etiqueta
Sin Etiquetas, Sea el primero en etiquetar este registro!

Ejemplares similares