Phosphoproteomics reveals novel modes of function and inter‐relationships among PIKKs in response to genotoxic stress

The DNA damage response (DDR) is a complex signaling network that relies on cascades of protein phosphorylation, which are initiated by three protein kinases of the family of PI3‐kinase‐related protein kinases (PIKKs): ATM, ATR, and DNA‐PK. ATM is missing or inactivated in the genome instability syn...

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Udgivet i:EMBO J
Main Authors: Schlam‐Babayov, Sapir, Bensimon, Ariel, Harel, Michal, Geiger, Tamar, Aebersold, Ruedi, Ziv, Yael, Shiloh, Yosef
Format: Artigo
Sprog:Inglês
Udgivet: John Wiley and Sons Inc. 2020
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Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC7809795/
https://ncbi.nlm.nih.gov/pubmed/33215756
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.15252/embj.2020104400
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