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ADP‐ribosylation of histone variant H2AX promotes base excision repair

Optimal DNA damage response is associated with ADP‐ribosylation of histones. However, the underlying molecular mechanism of DNA damage‐induced histone ADP‐ribosylation remains elusive. Herein, using unbiased mass spectrometry, we identify that glutamate residue 141 (E141) of variant histone H2AX is...

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Dettagli Bibliografici
Pubblicato in:EMBO J
Autori principali: Chen, Qian, Bian, Chunjing, Wang, Xin, Liu, Xiuhua, Ahmad Kassab, Muzaffer, Yu, Yonghao, Yu, Xiaochun
Natura: Artigo
Lingua:Inglês
Pubblicazione: John Wiley and Sons Inc. 2020
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Accesso online:https://ncbi.nlm.nih.gov/pmc/articles/PMC7809701/
https://ncbi.nlm.nih.gov/pubmed/33264433
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.15252/embj.2020104542
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