ADP‐ribosylation of histone variant H2AX promotes base excision repair

Optimal DNA damage response is associated with ADP‐ribosylation of histones. However, the underlying molecular mechanism of DNA damage‐induced histone ADP‐ribosylation remains elusive. Herein, using unbiased mass spectrometry, we identify that glutamate residue 141 (E141) of variant histone H2AX is...

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Bibliographic Details
Published in:EMBO J
Main Authors: Chen, Qian, Bian, Chunjing, Wang, Xin, Liu, Xiuhua, Ahmad Kassab, Muzaffer, Yu, Yonghao, Yu, Xiaochun
Format: Artigo
Language:Inglês
Published: John Wiley and Sons Inc. 2020
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Online Access:https://ncbi.nlm.nih.gov/pmc/articles/PMC7809701/
https://ncbi.nlm.nih.gov/pubmed/33264433
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.15252/embj.2020104542
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