Prioritizing transcriptional factors in gene regulatory networks with PageRank

Biological states are controlled by orchestrated transcriptional factors (TFs) within gene regulatory networks. Here we show TFs responsible for the dynamic changes of biological states can be prioritized with temporal PageRank. We further show such TF prioritization can be extended by integrating g...

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Udgivet i:iScience
Main Authors: Ding, Hongxu, Yang, Ying, Xue, Yuanqing, Seninge, Lucas, Gong, Henry, Safavi, Rojin, Califano, Andrea, Stuart, Joshua M.
Format: Artigo
Sprog:Inglês
Udgivet: Elsevier 2020
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Article
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC7809505/
https://ncbi.nlm.nih.gov/pubmed/33490923
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.isci.2020.102017
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