Androgen receptor and its splice variant, AR-V7, differentially induce mRNA splicing in prostate cancer cells

Prostate cancer (PCa) is dependent on the androgen receptor (AR). Advanced PCa is treated with an androgen deprivation therapy-based regimen; tumors develop resistance, although they typically remain AR-dependent. Expression of constitutively active AR variants lacking the ligand-binding domain incl...

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Udgivet i:Sci Rep
Main Authors: Rana, Manjul, Dong, Jianrong, Robertson, Matthew J., Basil, Paul, Coarfa, Cristian, Weigel, Nancy L.
Format: Artigo
Sprog:Inglês
Udgivet: Nature Publishing Group UK 2021
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Article
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC7809134/
https://ncbi.nlm.nih.gov/pubmed/33446905
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/s41598-021-81164-0
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