Inhibition of succinate dehydrogenase activity impairs human T cell activation and function

T cell activation is intimately linked to metabolism, as distinct metabolic requirements support the functional and phenotypical differences between quiescent and activated T cells. Metabolic transition from mitochondrial oxidative phosphorylation to aerobic glycolysis is crucial for a proper T cell...

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Veröffentlicht in:Sci Rep
Hauptverfasser: Nastasi, Claudia, Willerlev-Olsen, Andreas, Dalhoff, Kristoffer, Ford, Shayne L., Gadsbøll, Anne-Sofie Østergaard, Buus, Terkild Brink, Gluud, Maria, Danielsen, Morten, Litman, Thomas, Bonefeld, Charlotte Mennè, Geisler, Carsten, Ødum, Niels, Woetmann, Anders
Format: Artigo
Sprache:Inglês
Veröffentlicht: Nature Publishing Group UK 2021
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Article
Online Zugang:https://ncbi.nlm.nih.gov/pmc/articles/PMC7809054/
https://ncbi.nlm.nih.gov/pubmed/33446766
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/s41598-020-80933-7
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