Increased Production of IL-17A-Producing γδ T Cells in the Thymus of Filaggrin-Deficient Mice

Mutations in the filaggrin gene (Flg) are associated with increased systemic levels of Th17 cells and increased IL-17A production following antigen exposure in both humans and mice. In addition to Th17 cells, γδ T cells can produce IL-17A. The differentiation of γδ T cells to either IFNγ or IL-17A-p...

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Dettagli Bibliografici
Pubblicato in:Front Immunol
Autori principali: Jee, Mia Hamilton, Johansen, Jeanne Duus, Buus, Terkild Brink, Petersen, Trine Hilkjær, Gadsbøll, Anne-Sofie Østergaard, Woetmann, Anders, Ødum, Niels, Thyssen, Jacob Pontoppidan, White, Andrea Jane, Anderson, Graham, Geisler, Carsten, Bonefeld, Charlotte Menné
Natura: Artigo
Lingua:Inglês
Pubblicazione: Frontiers Media S.A. 2018
Soggetti:
Immunology
Accesso online:https://ncbi.nlm.nih.gov/pmc/articles/PMC5953325/
https://ncbi.nlm.nih.gov/pubmed/29867965
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.3389/fimmu.2018.00988
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