A cortical immune network map identifies distinct microglial transcriptional programs associated with β-amyloid and Tau pathologies

Microglial dysfunction has been proposed as one of the many cellular mechanisms that can contribute to the development of Alzheimer’s disease (AD). Here, using a transcriptional network map of the human frontal cortex, we identify five modules of co-expressed genes related to microglia and assess th...

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Detalhes bibliográficos
Publicado no:Transl Psychiatry
Main Authors: Patrick, Ellis, Olah, Marta, Taga, Mariko, Klein, Hans-Ulrich, Xu, Jishu, White, Charles C., Felsky, Daniel, Agrawal, Sonal, Gaiteri, Chris, Chibnik, Lori B., Mostafavi, Sara, Schneider, Julie A., Bennett, David A., Bradshaw, Elizabeth M., De Jager, Philip L.
Formato: Artigo
Idioma:Inglês
Publicado em: Nature Publishing Group UK 2021
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Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC7809035/
https://ncbi.nlm.nih.gov/pubmed/33446646
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/s41398-020-01175-9
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