UV-exposure, endogenous DNA damage, and DNA replication errors shape the spectra of genome changes in human skin

Human skin is continuously exposed to environmental DNA damage leading to the accumulation of somatic mutations over the lifetime of an individual. Mutagenesis in human skin cells can be also caused by endogenous DNA damage and by DNA replication errors. The contributions of these processes to the s...

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Detalhes bibliográficos
Publicado no:PLoS Genet
Main Authors: Saini, Natalie, Giacobone, Camille K., Klimczak, Leszek J., Papas, Brian N., Burkholder, Adam B., Li, Jian-Liang, Fargo, David C., Bai, Re, Gerrish, Kevin, Innes, Cynthia L., Schurman, Shepherd H., Gordenin, Dmitry A.
Formato: Artigo
Idioma:Inglês
Publicado em: Public Library of Science 2021
Assuntos:
Research Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC7808690/
https://ncbi.nlm.nih.gov/pubmed/33444353
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1371/journal.pgen.1009302
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