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The α2/α3GABA(A) receptor modulator TPA023B alleviates not only the sensory but also the tonic affective component of chronic pain in mice
Diminished synaptic inhibition in the spinal dorsal horn is a major contributor to pathological pain syndromes of neuropathic or inflammatory origin. Drugs that enhance the activity of dorsal horn α2/α3GABA(A)Rs normalize exaggerated nociceptive responses in rodents with neuropathic nerve lesions or...
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| Veröffentlicht in: | Pain |
|---|---|
| Hauptverfasser: | , , |
| Format: | Artigo |
| Sprache: | Inglês |
| Veröffentlicht: |
Wolters Kluwer
2021
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| Schlagworte: | |
| Online Zugang: | https://ncbi.nlm.nih.gov/pmc/articles/PMC7808355/ https://ncbi.nlm.nih.gov/pubmed/32773599 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1097/j.pain.0000000000002030 |
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