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Itch suppression in mice and dogs by modulation of spinal α2 and α3GABA(A) receptors

Chronic itch is a highly debilitating condition affecting about 10% of the general population. The relay of itch signals is under tight control by inhibitory circuits of the spinal dorsal horn, which may offer a hitherto unexploited therapeutic opportunity. Here, we found that specific pharmacologic...

詳細記述

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書誌詳細
出版年:Nat Commun
主要な著者: Ralvenius, William T., Neumann, Elena, Pagani, Martina, Acuña, Mario A., Wildner, Hendrik, Benke, Dietmar, Fischer, Nina, Rostaher, Ana, Schwager, Simon, Detmar, Michael, Frauenknecht, Katrin, Aguzzi, Adriano, Hubbs, Jed Lee, Rudolph, Uwe, Favrot, Claude, Zeilhofer, Hanns Ulrich
フォーマット: Artigo
言語:Inglês
出版事項: Nature Publishing Group UK 2018
主題:
オンライン・アクセス:https://ncbi.nlm.nih.gov/pmc/articles/PMC6089996/
https://ncbi.nlm.nih.gov/pubmed/30104684
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/s41467-018-05709-0
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