Itch suppression in mice and dogs by modulation of spinal α2 and α3GABA(A) receptors

Chronic itch is a highly debilitating condition affecting about 10% of the general population. The relay of itch signals is under tight control by inhibitory circuits of the spinal dorsal horn, which may offer a hitherto unexploited therapeutic opportunity. Here, we found that specific pharmacologic...

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Publié dans:Nat Commun
Auteurs principaux: Ralvenius, William T., Neumann, Elena, Pagani, Martina, Acuña, Mario A., Wildner, Hendrik, Benke, Dietmar, Fischer, Nina, Rostaher, Ana, Schwager, Simon, Detmar, Michael, Frauenknecht, Katrin, Aguzzi, Adriano, Hubbs, Jed Lee, Rudolph, Uwe, Favrot, Claude, Zeilhofer, Hanns Ulrich
Format: Artigo
Langue:Inglês
Publié: Nature Publishing Group UK 2018
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Article
Accès en ligne:https://ncbi.nlm.nih.gov/pmc/articles/PMC6089996/
https://ncbi.nlm.nih.gov/pubmed/30104684
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/s41467-018-05709-0
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